Alcuni libri oltre 2. Inquadra, scatta, scopri. Due libri a scelta tra quelli qui elencati possono essere presi in prestito in aggiunta angular d3 bubble chart due normalmente assegnati. Roma : Gaffi, Il Bollettino n. Il Bollettino riporta l'inventario, la collocazione e la descrizione. Roma : Carocci, Roma : Edizioni di storia e letteratura, Posner ; traduzione di Matteo Curtoni e Maura Parolini.
Bonfantini, Marina T. De Giovanni Traduzione di Maria Sole Abate. Siracusa : LetteraVentidue, Firenze : Le lettere, . In testa al front. Torino : Einaudi, c Traduzione di Andrea L. Traduzione di Claudia Lionetti. Cosenza : Pellegrini, stampa Pellegrini, . Balzac ; saggio introduttivo di Mariolina Bongiovanni Bertini ; traduzione e note di Daniela Schenardi. In copertina: con un'intervista inedita all'autrice.
Pontedera : Bibliografia e Informazione, Mondadori, In custodia. Parma : Guanda, To browse Academia.
Skip to main content. Log In Sign Up. Le RICA del nuovo millennio: tra tradizione e innovazione. Simona Turbanti. Bollettino aib, issnvol. Alcune chiavi di lettura dei dati: nella parte sinistra della tabella si trovano le voci del nuovo indice contrapposte ai paragrafi corrispondenti della RICA attuali, quan- do esistenti, sulla destra della griglia. Intestazione uniforme. Nome prevalentemente usato vs RICA Pseudonimi, nomi assunti, soprannomi, ecc. Pseudonimi collettivi e nomi convenzionali vs RICA Designazioni tradizionali vs RICA Cambiamento di nome 1.
Ultimo nome usato vs RICA Forme in lingue diverse vs RICA Forme con varianti ortografiche vs RICA Nomi di persone identificate con un titolo o un predicato nobiliare vs RICA 63 Nobi- li compresi quelli intestati al casato o cognome composto 2. Qualificazioni legate al nome vs RICA Qualificazioni per distinguere omonimi vs RICA Qualificazioni abituali vs RICA Qualificazioni cronologiche vs RICA Nomi impiegati come qualificazioni assente nelle RICA 3. Omonimi non distinti assente nelle RICA 4.
Cambiamento di nome, mentre i nobili sono trattati nel paragrafo 2. Quali- ficazioni legate al nome. Forme con varianti grammaticali, a sua volta compreso in 1. Scelta del nome. Scrittori medioevali, Scrittori bizantini, Scrittori greci, Scritto- ri medioevali, Scrittori latini.
Scorrendo oltre il nuovo indice ci si imbatte nel paragrafo 2.Federal government websites often end in. The site is secure. What does a fiduciary need to consider in evaluating the reasonableness of an agreement under which the service provider will be retaining "float" and what information is a service provider required to disclose to plan fiduciaries with respect to such arrangements in order to avoid engaging in a prohibited transaction?
A number of financial services providers, such as banks and trust companies, acting as non-discretionary directed trustees or custodians maintain general or omnibus accounts to facilitate the transactions of employee benefit plans.
The service provider may retain earnings "float" resulting from the anticipated short-term investment of funds held in such accounts. Typically, these accounts hold contributions and other assets pending investment directions from plan fiduciaries.
In addition, fiduciaries transfer funds to a general account of the financial institution in connection with issuance of a check to make a plan distribution or other disbursement. Funds are then held in the account earning interest until checks are presented for payment.
In Advisory Opinion A, the Department expressed the view that a trustee's exercise of discretion to earn income for its own account from the float attributable to outstanding benefit checks constitutes prohibited fiduciary self-dealing under section b 1 of ERISA. Advisory Opinion A dealt with a situation where there was no disclosure of the float to employee benefit plan customers. Therefore, to avoid problems, banks should, as part of their fee negotiations, provide full and fair disclosure regarding the use of float on outstanding benefit checks.
In general, the concepts of open negotiation and full and fair disclosureas used in the letter, are intended to ensure that service providers provide sufficient information concerning such arrangements so that plan fiduciaries can make informed assessments concerning the prudence of the arrangements. Further, those concepts are intended to ensure that the amount of the service provider's compensation is determined and approved by a fiduciary independent of the service provider so that prohibited self-dealing is avoided.
Typically, a service agreement will provide that, in addition to other specifically identified or scheduled fees, the service provider may also receive compensation in the form of earnings on funds awaiting investment or reinvestment or funds pending distribution.
According to the investigations, however, there is little or no disclosure of specific information regarding compensation earned in the form of float. Further guidance, therefore, has been requested concerning the obligations of plan fiduciaries and service providers regarding float arrangements and disclosures. Obligations of P lan Fiduciary - In selecting a service provider, plan fiduciaries must, consistent with the requirements of section aact prudently and solely in the interest of the plans participants and beneficiaries and for the exclusive purpose of providing benefits and defraying reasonable expenses of administering the plan.
Except as provided in sectionplan fiduciaries also have an obligation under section a not to cause the plan to engage in certain transactions, including a direct or indirect furnishing of goods, services or facilities between the plan and a party in interest. Section b 2 exempts from the prohibitions of section a any contract or reasonable arrangement with a party in interest, including a fiduciary, for office space, or legal, accounting or other services necessary for the establishment or operation of the plan, if no more than reasonable compensation is paid therefor.
In addition, such process should be designed to avoid self-dealing, conflicts of interest or other improper influence.
In circumstances where a service provider may receive compensation in the form of float, we believe the selection and monitoring process engaged in by the responsible fiduciary should include:. Additionally, a plan fiduciary must periodically monitor compliance by the service provider with the terms of the agreement and the reasonableness of compensation under the agreement in order to ensure continuation of the agreement meets the requirements of sections a 1and b 2.
Obligations of Service Providers - The primary issue for service providers with float arrangements is whether the provider has disclosed to its employee benefit plan customers sufficient information concerning the administration of its accounts holding float so that the customer can reasonably approve the arrangement based on an understanding of the service provider's compensation.
Moreover, the arrangement must not permit the service provider to affect the amount of its compensation in violation of section b 1 e. For example, even where a service provider discloses in its service agreement that additional compensation may be paid to the service provider as a result of float, a prohibited transaction may nonetheless result to the extent that the service provider exercises discretionary authority or control sufficient to cause a plan to pay additional fees to the provider.
La biblioteca digitale : definizioni, ingredienti e problematiche
As noted in Advisory Opinion A, a fiduciary's decision to handle plan assets in such a way as to benefit itself constitutes prohibited self-dealing, without regard to the status of the funds after they are placed in a disbursement or other account. It is the view of this Office that, in connection with a service agreement pursuant to which the service provider may be retaining float as part of its compensation, the service provider can avoid self-dealing with respect to such earnings by taking the following steps:.Opioid receptor subtypes may reflect hetero-dimerization of opioid receptors with each other or with other 7TM receptors Jordan and Devi,but evidence for heterodimers in native cells is equivocal.
A distinct met-enkephalin receptor lacking structural resemblence to the opioid receptors listed has been identified ENSG and termed an opioid growth factor receptor see Zagon et al. Bailey CP, Connor M Opioids: cellular mechanisms of tolerance and physical dependence.
Curr Opin Pharmacol 5 : 60— Opioid dependence and addiction during opioid treatment of chronic pain. Pain : — Trends Pharmacol Sci 28 : 23— Pharmacol Ther : — The endomorphin system and its evolving neurophysiological role. Pharmacol Rev 59 : 88— Henriksen G, Willoch F Imaging of opioid receptors in the central nervous system.
Brain : — Opioid receptors: from binding sites to visible molecules in vivo. Neuropharmacology 56 Suppl. Koch T, Hollt V Role of receptor internalization in opioid tolerance and dependence. J Biol Chem : — Lambert DG Numerous and frequently-updated resource results are available from this WorldCat.
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Opioid and opioid-like
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Please enter recipient e-mail address es. The E-mail Address es you entered is are not in a valid format.Crystal-structure analysis reveals a continuous helical conformation encompassing the segment of residues 2—10 of peptide 1. The N terminus of the peptide is partially unfolded in crystals. The presence of seven intramolecular hydrogen bonds is also established by using solvent dependence of NH chemical shifts.
This synthesis was approached by a conventional fragment-condensation strategy, with Boc and OMe groups for N- and C-terminal protection, respectively.
Andrei Yu. Panibratov
Single crystals that were suitable for x-ray diffraction were obtained by slow evaporation from acetonitrile. X-Ray Diffraction. The 3D x-ray diffraction data were collected on a crystal of 0. A resolution of 0. The structure was solved by direct phase determination and refined by full-matrix least-squares refinement on F 2 data The hydrogen atoms were placed in idealized positions and allowed to ride on the C or N atom to which they were bonded. A cocrystallized CH 3 CN molecule, which occurs in a void between peptide molecules merely as a space filler, has large thermal parameters that indicate disorder.
Crystal data were as follows: C 68 H N 11 O C 2 H 3 N, formula weight 1, NMR Spectroscopy. All 2D data were collected in phase-sensitive mode by using the time-proportional phase incrementation TPPI method.
Sets of 1, and data points were used in the t 2 and t 1 dimensions, respectively. A shifted square sine-bell window was used before processing. Examples of partial unfolding of Aib residues at the N terminus in helical peptides have been reported Chiral reversal of Aib residues at the C terminus of helical peptides is not unusual 12 X-ray structures.
The observed intramolecular and intermolecular hydrogen bond parameters are summarized in Table 2.
Table 2 shows that the overall helical conformation is stabilized by seven potential intramolecular hydrogen-bond interactions. Packing in Crystals. Helices are packed by efficient intermolecular hydrogen bonds in a head-to-tail fashion Fig.
The N O11 distance of 3. The CH 3 CN molecule fills vacant spaces between peptide molecules, with a closest approach of 3. The three O. HN bonds in the head-to-tail region that link the helices into infinite columns. Solution Conformations. Good chemical-shift dispersion permitted complete assignment of all backbone proton resonances.
The observed NOEs are completely consistent with the helical conformation determined in crystals. The number of intramolecular hydrogen bonds in peptide 1 in CDCl 3 solution was determined in a solvent-perturbation experiment by monitoring the changes in amide proton chemical shifts upon the addition of the hydrogen-bonding solvent DMSO Fig.
Only the two N-terminal amide protons of Val-1 and Ala-2 show more pronounced downfield shifts, with increasing concentrations of DMSO. The chemical shifts of all other NH groups are insensitive, confirming their shielding from the solvent and implicating them in intramolecular hydrogen bonding.
These results support a continuous helical conformation encompassing the entire length of the peptide. Key NOEs are indicated. Calculated distances are from the segments in crystal structures.Associazione italiana biblioteche", che ha mantenuto fino al I legami conducono ai testi integrali eventualmente disponibili.
Non sono compresi accessi secondari o rinvii; nel dubbio, usare la funzione di Ricerca del browser. The journal was born, in its paper edition, in with the name "Notizie AIB: Bollettino dell'Associazione italiana biblioteche"; in it changed the name in "Bollettino d'informazioni" and mantained it until In the new series, with the ongoing name "Bollettino AIB", began; in the same year the electronic edition of the journal began.
Links point to full texts, if available. Added entries or references are not provided; if in doubt, use the Find command of your browser. The value of public libraries: a methodological discussion and empirical study applying the contingent valuation method.
Oslo: Unipub, Rec. Trickey and Susi Woodhouse. London: Library Association, Rec. Competing with knowledge: the information professional inthe knowledge management age Rec.
Performance measurement in library and information services. London: Aslib, Rec. Le metier de documentaliste. Paris: Editions du Cercle de la librairie, Rec. Paris: Cercle de la librairie, Rec. Access, ownership and resource sharingSul H. Lee editor. Access servicesedited by Gillian M. Achieving cultural change in network librariesedited by Bruce J. Reid and William Foster. Aldershot: Gower, Rec.
Milano: Ed. Bibliografica, Rec. Acquisitions and collection development in the humanitiesIrene Owens editor. Binghamton: The Haworth Press, Rec. Principi dell'IFLA per la cura e il trattamento dei materiali di biblioteca. Edizione italiana a cura della Commissione nazionale Biblioteche e servizi nazionali. Roma: Associazione italiana biblioteche, Rec. Patrizia Calabresi : n. Administration and management in health sciences librariesedited by Rick B.
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